To further explore the role of interleukin-2 (IL-2) in cardiac function, we investigated its effects on the intracellular calcium transient and the activity of sarcoplasmic reticulum (SR) Ca2+-ATPase in rat cardiomyocytes. IL-2 (200 U/ml) decreased the amplitude of …
contact1/8/2003· To further explore the role of interleukin-2 (IL-2) in cardiac function, we investigated its effects on the intracellular calcium transient and the activity of …
contact2/5/2003· To further explore the role of interleukin-2 (IL-2) in cardiac function, we investigated its effects on the intracellular calcium transient and the activity of …
contact1/9/2003· To further explore the role of interleukin-2 (IL-2) in cardiac function, we investigated its effects on the intracellular calcium transient and the activity of …
contact2/5/2003· Other Publications Drug Metabolism and Disposition Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Pharmacological Reviews …
contactInterleukin-2 Increases Activity of Sarcoplasmic Reticulum Ca2-ATPase, but Decreases Its Sensitivity to Calcium in Rat Cardiomyocytes CHUN-MEI CAO, QIANG XIA, IAIN C. …
contact25/2/2003· The purpose of the present study was to investigate whether interleukin-2 (IL-2) changes the activity of sarcoplasmic reticulum (SR) Ca(2+) ATPase, sarcolemmal …
contact1/2/2003· Interleukin-2 increases activity of sarcoplasmic reticulum Ca2+-ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes. Cao CM, Xia Q, Bruce IC, …
contact13/3/1996· Prolonged exercise has been shown to cause disruption of intracellular calcium homeostasis in skeletal muscle, which is normally maintained by the sarcoplasmic …
contactWe hypothesized that endoplasmic reticulum (ER) calcium increases enhance the folding, trafficking and function of these mutant misfolding- and degradation-prone lysosomal …
contactInterleukin-2 Increases Activity of Sarcoplasmic Reticulum Ca2-ATPase, but Decreases Its Sensitivity to Calcium in Rat Cardiomyocytes CHUN-MEI CAO, QIANG XIA, IAIN C. BRUCE, XIONG ZHANG, CHEN FU ...
contact1/2/2003· Effect of interleukin-2 on the activity of Ca 2+ ATPase and Na +/K + ATPase of sarcoplasmic reticulum and sarcolemma February 2003 Sheng li xue bao: [Acta physiologica Sinica] 55(1):83-90
contact4/1/2016· Interleukin-2 increases activity of sarcoplasmic reticulum Ca2 + −ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes. J Pharmacol Exp Ther. 2003; 306 :572–80. doi: 10.1124/jpet.102.048264.
contact19/9/2003· Impact of Increased SR Ca 2+ Leak Versus SERCA and NCX Changes. Most Ca 2+ released via Ca 2+ sparks returns to the SR due to stronger Ca 2+ transport by the SR Ca 2+ -ATPase versus NCX. However, the SR unloading effect of enhanced leak would be synergistic with the typical SERCA and NCX changes seen in HF.
contactEngagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation-contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac contractile activity are ...
contact13/3/1996· Prolonged exercise has been shown to cause disruption of intracellular calcium homeostasis in skeletal muscle, which is normally maintained by the sarcoplasmic reticulum (SR) Ca2+-ATPase. We have investigated the response of this enzyme to increased intracellular calcium levels by investigating the functional and physical …
contactIn contract, the sarcoplasmic reticulum (SR) Ca 2+ release channel/ryanodine receptor (RyR2) is hyperphosphorylated in AF at both protein kinase A (PKA) and Ca 2+ /calmodulin-kinase II (CaMKII) sites. This might be caused by reduced PP1 activity, as a result of hyperphosphorylation (and thus activation) of inhibitor-1 at Thr35 that reduces SR ...
contact4/1/2016· Cao CM, Xia Q, Bruce IC, Zhang X, Fu C, Chen JZ. Interleukin-2 increases activity of sarcoplasmic reticulum Ca2 + −ATPase, but decreases its sensitivity to calcium in rat cardiomyocytes. J Pharmacol Exp Ther. 2003;306:572–80. Article CAS PubMed
contact12/11/2021· As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and function, and SERCA activity is susceptible to …
contact23/7/2020· Several metabolic disease models have shown that dysregulation of sarcoplasmic reticulum Ca2+ ATPase ... of MLC 20 phosphorylation 64,65 and Rho kinase activity is increased in MetSyn condition 66 ...
contactEngagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation-contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac contractile activity are ...
contact1/1/2003· Time for primary review 25 days. 1 Introduction The sarcoplasmic reticulum (SR) is an intracellular membrane system in cardiac cells, which plays a predominant role in cardiac excitation–contraction coupling and cardiac contractility. A 1000-fold Ca 2+-gradient is maintained across the cardiac sarcoplasmic reticulum membrane by the SR Ca 2+ …
contact21/2/2018· The calcium pump (a.k.a. Ca 2+ -ATPase or SERCA) is a membrane transport protein ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium transporter, SERCA maintains the low cytosolic calcium level that enables a vast array of signaling pathways and physiological processes (e.g. synaptic transmission, …
contact12/11/2021· As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction. SERCA function is closely associated with muscle health and function, and SERCA activity is susceptible to …
contact11/5/2021· Introduction In mammalian hearts, Ca 2+ release from and reuptake into the sarcoplasmic reticulum (SR) is tightly regulated for proper excitation–contraction coupling (ECC) (Bers, 2002a).At steady state, during each ECC cycle, Ca 2+ is released from the SR through ryanodine receptors (RyRs) during systole, and the same amount of Ca 2+ is …
contact23/7/2020· Several metabolic disease models have shown that dysregulation of sarcoplasmic reticulum Ca2+ ATPase ... of MLC 20 phosphorylation 64,65 and Rho kinase activity is increased in MetSyn condition 66 ...
contactTetanic [Ca 2+] i and force are decreased in Tfam KO muscle fibres. ( A and B) Original [Ca 2+] i and force records obtained from 100 Hz tetani in a Tfam KO and a control FDB single muscle fibre. ( C and D) [Ca 2+] i and force in tetani of different frequencies in Tfam KO (filled circle, dashed lines; n = 6) and control (open circle, full lines; n = 7) fibres; 100 Hz …
contact15/1/2015· Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in ... Phosphorylation of endogenous PDE3A by rPKAc increased cAMP-hydrolytic activity ...
contact16/7/2022· Arg324 of sarcoplasmic reticulum Ca2+-ATPase forms electrostatic interactions with the phosphate moiety of phospholipids in most reaction states, and a hydrogen bond with Tyr122 in other states
contactsarcoplasmic reticulum, intracellular system of closed saclike membranes involved in the storage of intracellular calcium in striated (skeletal) muscle cells. Each segment of the sarcoplasmic reticulum forms a cufflike structure surrounding a myofibril, the fine contractile fibres that extend the length of striated muscle cells. By regulating the …
contactEngagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation-contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac contractile activity are ...
contact21/2/2018· The calcium pump (a.k.a. Ca 2+ -ATPase or SERCA) is a membrane transport protein ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium transporter, SERCA maintains the low cytosolic calcium level that enables a vast array of signaling pathways and physiological processes (e.g. synaptic transmission, …
contact1/4/2010· Indeed, sustained increases in Ca 2+ spark frequency are generally associated with factors that increase the SR Ca 2+ content, reflecting an increase in the influence of luminal Ca 2+ on RyR2 . Against this background, the sustained increase in Ca 2+ spark frequency associated with TNF-α and IL-1β treatment, combined with a decrease in SR …
contact14/6/2018· Enhanced sarcoplasmic reticulum Ca 2+ leak and increased Na +-Ca 2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation 2012; 125: ...
contact11/5/2021· Introduction In mammalian hearts, Ca 2+ release from and reuptake into the sarcoplasmic reticulum (SR) is tightly regulated for proper excitation–contraction coupling (ECC) (Bers, 2002a).At steady state, during each ECC cycle, Ca 2+ is released from the SR through ryanodine receptors (RyRs) during systole, and the same amount of Ca 2+ is …
contact2/2/2021· Preliminary findings implicate possible local tubule-sarcoplasmic triadic domains containing reduced [Ca 2+ ] TSR in the observed upregulation of Nav1.4 function following CPA-induced SR Ca 2+ depletion. Skeletal muscle Na + channels possess Ca 2+ - and calmodulin-binding sites implicated in Nav1.4 current ( I Na ) downregulation following …
contactThe sarcoplasmic reticulum (SR) is a membrane-bound structure found within muscle cells that is similar to the smooth endoplasmic reticulum in other cells.The main function of the SR is to store calcium ions (Ca …
contact26/6/2020· In cardiomyocytes, to carry out cell contraction, the distribution, morphology, and dynamic interaction of different cellular organelles are tightly regulated. For instance, the repetitive close apposition between …
contactTetanic [Ca 2+] i and force are decreased in Tfam KO muscle fibres. ( A and B) Original [Ca 2+] i and force records obtained from 100 Hz tetani in a Tfam KO and a control FDB single muscle fibre. ( C and D) [Ca 2+] i and force in tetani of different frequencies in Tfam KO (filled circle, dashed lines; n = 6) and control (open circle, full lines; n = 7) fibres; 100 Hz …
contact11/11/2021· Naturally found chrysosplenol-C (4',5,6-trihydroxy-3,3',7-trimethoxyflavone) increases the contractility of cardiac myocytes independent of b-adrenergic signaling. We investigated the cellular mechanism for chrysosplenol-C-induced positive inotropy. Global and local Ca2+ signals, L-type Ca2+ current (ICa), and contraction were measured from …
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